Emergency services responded to reports of a house fire at the corner of Foote and Annear streets in Acacia Ridge around 1pm on Saturday.
The fast-moving blaze completely destroyed the home, with the man's body discovered inside the property after firefighters brought the fire under control.
Queensland Fire and Emergency Services crews worked to contain the blaze and prevent it from spreading to neighbouring properties. The extent of damage to surrounding homes has not been reported.
Police have established a crime scene as investigations into the cause of the fire begin. The circumstances surrounding the man's death remain unclear, and formal identification is yet to take place.
The incident has shocked the local Acacia Ridge community, with residents expressing concern about the tragic loss of life.
Fire investigators will examine the scene to determine what sparked the blaze that led to the destruction of the home and the man's death.
Queensland Police are expected to prepare a report for the coroner as part of standard procedure for deaths in such circumstances.