Brand, 51, has pleaded not guilty to three counts of rape, three counts of sexual assault and one count of indecent assault. The charges involve six women, with alleged offences between 1999 and 2009.
Prosecutor Riel Karmy-Jones told jurors on Wednesday (local time) that the six women, who do not know each other, were assaulted in "a hotel room, workplaces, a toilet cubicle in a bar and at his home address".
She said that at the time Brand had an "indiscriminate and voracious" desire for sexual contact, and "women were simply a means to an end". The prosecutor described Brand as a "flirt with a huge sexual appetite – childlike in his expectation that his every desire should be met".
"He was ruthless, he was calculating, he was manipulative. And, the prosecution say, he was a sexual predator," Karmy-Jones said.
Brand listened intently from the dock as the prosecutor described each of the alleged incidents. The earliest allegation involves Brand allegedly raping a woman in a hotel room during the Labour Party's annual conference in Bournemouth in 1999, when Brand was a rising stand-up comedian performing in a cabaret on the fringe of the event.
Two years later, another woman alleges, Brand tried to drag her into the men's toilet at the office building where she worked. "There can be little doubt as to what Mr Brand's intention was," Karmy-Jones said.
A third woman alleges that in 2004 Brand orally raped her in the toilets of a London bar, telling her "Don't be a spoilsport" when she asked him to stop.