organisation

Mount Sinai

Hospital and medical research institution in New York City

Health & Medicine · 19 Oct 2026Mount Sinai Study Identifies Three Brain Pathways Crucial for Deep Brain Stimulation in Depression

A study published October 1 in the American Journal of Psychiatry by researchers at Mount Sinai has identified three white matter pathways in the brain that are consistently associated with lasting improvement in patients receiving deep brain stimulation (DBS) for severe, treatment-resistant depression. The findings highlight that the precise targeting of these connections through electrode placement could be critical for successful treatment, with millimeters in positioning potentially determining outcomes.