In May, health officials in California and Washington formally asked the CDC to validate a new method for testing measles that could process large numbers of samples quickly. After a two-month wait, the agency rejected the request, a decision that the West Coast Health Alliance says undermines preparedness for major outbreaks.
The alliance, which represents health departments in California, Hawaii, Oregon and Washington, sent a letter to Dr. Schwartz on October 22 urging her to reverse the decision and publish a validated high-throughput measles assay. Such a test, the officials wrote, would “dramatically strengthen” laboratories’ ability to respond quickly to outbreaks and also help prepare for other pathogens such as Ebola or hantavirus.
Currently, public health laboratories rely on lower-volume individual PCR tests for measles. During the Covid-19 pandemic, many labs acquired high-throughput equipment such as the Hologic Panther Fusion platform, which can process up to 500 tests in eight hours. But no high-throughput test for measles has been published or validated by the CDC.
Texas state laboratories developed their own high-volume measles test during an outbreak in west Texas last year, but the protocol has not been distributed or published. The CDC has reportedly studied that test and one from ARUP Laboratories, but the West Coast officials said the studies “were not full validations or a comprehensive comparison.” The alliance is asking the CDC to develop an assay for the Panther Fusion and publish the protocol so any lab can run it.
“If a large outbreak were to occur in our region, without high-throughput capacity, it would be more difficult to scale up diagnostic testing appropriately, impairing patient care and public health investigation,” the letter said.
Emily Hilliard, a spokesperson for the US Department of Health and Human Services (HHS), said the CDC is “ensuring state and local health departments have the support needed to strengthen measles detection and outbreak response” and is “prioritizing emerging technologies” to respond to the current measles outbreak. She did not answer questions about whether the agency plans to validate a high-throughput measles assay.
