Dengue vaccine now available in Australia after spike in cases and new ATAGI advice

Melbourne student's Bali ordeal highlights risk as cases surge in tropical destinations

By LineZotpaper
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Melbourne student Ella Stiebel thought her brain would explode as she prepared to fly home from Bali after a family hike left her confined to a hotel room with severe dengue fever. Her ordeal comes as the Qdenga vaccine becomes commercially available in Australia following updated advice from the Australian Technical Advisory Group on Immunisation (ATAGI), recommending the shot for some travellers particularly those who have already contracted the disease. Cases of the mosquito-borne virus are spiking in popular tourist destinations and have triggered a state of emergency in parts of Florida.

Ella Stiebel, a student social worker from Melbourne, fell ill days after a family hike through the Balinese jungle. She became too sick to eat, too weak to walk, and so sensitive to light that even looking at a phone screen made her wince. A blood test after 2½ weeks confirmed dengue. The night before flying home, Stiebel had a panic attack, fearing the altitude on the plane would make her brain explode.

Dengue is a viral fever spread by mosquitoes. While most patients recover after a week, some develop a severe hemorrhagic form requiring hospitalisation, causing internal bleeding and potentially death. Catching the disease a second time can disrupt the immune system catastrophically, according to Dr Deb Mills, medical director of the Travel Medicine Alliance. "People get bleeding into their skin, and basically, their blood pressure drops, and they can die. So it can be really, really bad," she said.

An estimated three in four cases are asymptomatic. ATAGI notes that half of Australia's top 10 most-visited places — Indonesia, Thailand, India, Vietnam and Fiji — have frequent or persistent dengue transmission. There are four types of the virus; the Qdenga vaccine provides protection against all four.

The vaccine has been available for a couple of years but required extensive paperwork and cost $500 per dose, with two doses needed. "It was a hefty expense," Mills said. More supply of the live-attenuated virus is now expected, improving access.

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Analysis

Why This Matters

  • Australian travellers to popular destinations in Southeast Asia and the Pacific face increasing dengue risk as cases surge globally.
  • The second infection can cause severe hemorrhagic fever, making vaccination particularly important for those who have already had dengue.
  • Wider vaccine availability and updated ATAGI advice could reduce the number of hospitalisations and deaths among returning travellers.

Background

Dengue fever is a mosquito-borne viral disease endemic in many tropical and subtropical regions. It has four serotypes, and infection with one does not provide immunity against the others. Secondary infections are more likely to result in severe disease. The Qdenga vaccine (TAK-003) is a live-attenuated vaccine that has been approved in several countries. In Australia, it was previously available only through complex arrangements and at high cost.

Key Perspectives

Travellers and at-risk individuals: Need clear guidance on their personal risk based on travel history and destination, and affordable access to the vaccine. Australian health authorities and ATAGI: The updated recommendation aims to protect travellers, especially those who have had dengue before, from severe outcomes. Medical experts like Dr Deb Mills: Emphasise the seriousness of second infections and the importance of vaccination, while noting previous cost and access barriers that limited uptake.

What to Watch

  • Uptake of the Qdenga vaccine among eligible travellers and any changes to its price.
  • Ongoing dengue outbreaks in Florida and other regions beyond traditional endemic areas.
  • Whether further supply increases drive down the $500-per-dose cost and simplify the prescribing process.

Sources

Zotpaper

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