Donaldson hurt his groin at training on Tuesday, and the Wallabies opted against risking him for what will be their last Test on home soil this year. With regular first-choice No.10 Carter Gordon also unavailable, Declan Meredith will start at flyhalf for just the fourth time since debuting against France in July.
Western Force recruit Harry McLaughlin-Phillips has been promoted to the bench and is poised to become Wallaby 1001.
Coach Les Kiss has made four changes from the side that lost 50-19 at Eden Park. Len Ikitau's concussion sees Harry Potter named on the wing, with Joseph-Aukuso Suaalii shifting to outside centre to partner Isaac Henry in the midfield.
The other two changes come in the front row. Aidan Ross rotates with Angus Bell at loosehead prop, and Ross is joined by his Queensland teammate Josh Nasser, who replaces Brandon Paenga-Amosa at hooker. Paenga-Amosa has been rested after a heavy schedule.
The Wallabies will be eager to end a 12-Test drought against New Zealand on Saturday, with the match representing their final home appearance of the year.