The pervasive presence of microplastics in drinking water, human blood, arteries, and brains has long raised health concerns, but direct evidence of harm remains elusive. A new study led by Wei Min, a chemist at Columbia University, offers a potential mechanism: the particles themselves may produce reactive chemicals.
Min's lab has focused on microdroplet chemistry—how water behaves when broken into tiny droplets. These droplets are known to generate reactive oxygen species (ROS), molecules that can damage proteins, lipids, and DNA. "ROS will essentially bump into proteins, lipids, DNA, and cause damage," Min said. "You could break a DNA strand into segments. You could mutate DNA; you could misfold proteins."
The finding suggests that microplastics are not merely passive contaminants but could actively create chemical hazards. "Whether microplastics can directly cause human disease is still being researched," Min noted, placing the work as a step toward answering that question.