Police were called to the intersection of Beaudesert Road and Paradise Road in Acacia Ridge about 6.25pm following reports a pedestrian had been struck by a Volkswagen Golf.
The Queensland Ambulance Service sent four teams to the scene, where paramedics treated a man with what a spokesperson described as "injuries not compatible with life". He died at the scene.
The 50-year-old driver of the Volkswagen remained at the scene and is assisting officers with their inquiries.
Police have urged anyone who witnessed the crash or has dashcam footage from the area to come forward.