The arrests came after an aggravated burglary at a property on Clonaig Street in Brighton East, where an occupant was woken by noise inside the home just after 5.30am. Police said two vehicles were stolen and the offenders fled, with no one injured during the incident.
One of the vehicles, a Nissan 4WD, was observed being driven erratically on EastLink and was monitored by police through multiple eastern and south-eastern suburbs before it was intercepted in Chadstone just after midday.
"Six occupants of the vehicle were arrested and are currently being interviewed," police said in a statement. A second vehicle was also recovered after a crash in Endeavour Hills.
All outbound lanes on the Monash Freeway at Warrigal Road were closed about midday on Tuesday as specialist officers, including armed police and detectives, surrounded the stolen vehicle. Images from the scene showed multiple people lying face down on the bitumen, with marked and unmarked police cars gathered around the vehicle.
Motorists faced significant delays on the freeway, one of Melbourne's major arterial roads, during the operation.