MIT researchers develop nanoparticle technique to engineer cancer-killing cells inside the body
In vivo reprogramming of NK cells could simplify CAR NK therapy
MIT scientists have created a method to convert immune cells into cancer fighters directly inside the body, using lipid nanoparticles to deliver mRNA instructions to natural killer (NK) cells. This approach, described in a study published in Nature Biotechnology, could bypass the complex, time-consuming process of engineering CAR NK cells outside the body. In mouse models, three of five treated mice with aggressive melanoma experienced complete remission; tumors were eliminated in humanized mice with T cell lymphoma after five injections, while liver tissue healed after one injection in mice with autoimmune hepatitis.