Pancreatic cancer rewrites its DNA to resist treatment, single-cell study reveals
NYU Langone researchers identify MYC and TIGIT genes as key drivers of tumour evolution, opening new therapeutic targets
Scientists at NYU Langone Health have mapped how pancreatic cancer constantly reshapes its genetic makeup to become more aggressive, spread, and evade treatment, using single-cell analysis of nearly half a million tumour cells. The study, published October 13 in Nature Genetics, found that blocking activity of the MYC gene can push aggressive cancer cells back toward a less dangerous state, suggesting a potential new approach to treating one of the deadliest cancers.