Sperm RNA 'aging cliff' found in mice; similar pattern seen in human samples
Study identifies abrupt RNA-fragment shift in midlife mouse sperm; Chen says human parallels suggest a conserved molecular signature of aging
A study published in The EMBO Journal has identified a sharp “aging cliff” in mouse sperm where the composition of RNA fragments changes abruptly in middle age, and the same pattern was confirmed in human sperm from two separate donor groups. The findings could help researchers understand how sperm function may decline with age.