The flaw, tracked as CVE-2026-76519, carries a CVSS severity score of 9.8 out of 10 and stems from improper handling of email attachments in the product's Advanced Malware Protection (AMP) feature. In advisories published Wednesday, Cisco and the US government said attackers had exploited the vulnerability before a fix was available. The US Cybersecurity and Infrastructure Security Agency (CISA) added the bug to its Known Exploited Vulnerabilities catalog and set a Saturday deadline for federal agencies to patch.
Cisco said it became aware of active exploitation in October. A spokesperson said the issue affects a limited number of customers but declined to say how many appliances had been compromised or what attackers were doing with the access they gained. The company said it strongly urges customers to upgrade to a fixed software release and follow hardening guidance in its advisory.
The vulnerability affects physical and virtual Secure Email Gateway appliances running vulnerable releases of Cisco AsyncOS Software when both of two conditions are met: the File Reputation service, part of AMP, is enabled and assigned to a mail policy, and Content Scanner Tools is earlier than version 25.3.0.5525. Cisco said there are no workarounds and recommends customers running releases earlier than v16.5 migrate to 16.5.0-780.
This is the second zero-day in the Secure Email Gateway in as many months. In mid-September, Cisco warned that criminals were exploiting a similar email-to-root bug tracked as CVE-2026-76461, and in January attackers exploited CVE-2025-20393, another AsyncOS flaw, to break into appliances and install persistence mechanisms. That bug eventually scored a perfect 10 on the CVSS scale.