Enumerating Tool Choices Beats Sampling Them in Genomic Reasoning

Full-Group Policy Optimization evaluates every possible tool subset, improving accuracy while reducing reward-model calls and unnecessary tool use.

Top University
Haoyue Liu · Xiaoyu Ma · Ye Chen · Zhichao Wang · Xiaoying Tang

The Chinese University of Hong Kong, Shenzhen · Shenzhen Future Network of Intelligence Institute (FNii-Shenzhen) · Xi’an Jiaotong University

Research Digest··2 min read

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Enumerating all tool subsets during training outperforms sampling-based policy optimization for genomic tool selection.

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Standard reinforcement learning for tool selection uses sampling (GRPO), but in domains with a small, enumerable set of tools this degrades as the policy concentrates on preferred subsets. Sampled rewards collide, the advantage signal vanishes, and training stalls. The authors propose FGPO, which scores every possible tool subset and precomputes rewards for all question-subset pairs, eliminating sampling and frozen-reasoner calls during training. Across five reasoners and three genomic benchmarks, FGPO outperforms GRPO by 6.75 points on average and up to 14.20, while also reducing tool usage and reward evaluations.

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