Fold’EM treats structure determination as joint inference over an atomic protein model and particle-specific latent variables, including viewing orientation and conformational assignment.
Fold’EM infers atomic structures directly from cryo-EM particle images
The framework combines protein-model priors with sparse, noisy particle measurements, bypassing three-dimensional density reconstruction and subsequent model fitting.
Top University
Advaith Maddipatla · Märt-Erik Mäeots · Marco Pegoraro · Nikolaus Dräger · Roberto Covino · Sanketh Vedula · +2 more
Institute of Science and Technology Austria · University of Zurich · Frankfurt Institute for Advanced Studies · Princeton University · Broad Institute of MIT and Harvard
Research Digest··2 min read
Maddipatla et al.
Why this paper
From Princeton University and 4 others
In one line
Fold'EM infers atomic structures directly from cryo-EM particle images by combining protein structure priors with particle evidence, bypassing density reconstruction.
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