Police were called to Brookhouse Road in Meir at about 23:45 BST on Friday following reports of violence. A man in his late teens was pronounced dead at the scene, while another man, also in his late teens, was taken to hospital where he remains in a critical but stable condition.
Two 18-year-old men, a 20-year-old man and a 17-year-old boy, all from Stoke-on-Trent, have been arrested on suspicion of murder. The 17-year-old has also been arrested on suspicion of attempted murder. All four remain in police custody.
A cordon remains in place on Brookhouse Road as detectives investigate the circumstances of the attack. Detective Inspector Katie Gregory described the incident as a devastating time for those affected and moved to reassure the local community. She said: "I'd like to reassure the community that there is no wider risk to them, and we are doing all we can to understand the circumstances that led to this tragic incident."
Police have urged anyone with information about the attack to come forward.