Homicide squad detectives are at the scene in Reservoir, where a man was fatally shot on Tuesday night. Police said the offenders left the area in a white-coloured vehicle after setting a car alight on Robinvale Avenue in Thomastown shortly after the shooting.
Mahoneys Road was closed in both directions overnight but has since reopened. A crime scene remains in place as investigators work to formally identify the victim.
No arrests have been made. The shooting is the latest in a string of gun violence across Melbourne over the past fortnight. On October 13, shots were fired into a home in Caroline Springs. The following day, a road-rage incident turned into a drive-by shooting in Tullamarine. On October 15, a man was shot dead at his front door in Wollert, and three days later two men were critically injured in a shooting in Dallas.