The strike, which hit a depot storing ammunition for Ukraine's military near a residential area, was captured in videos shared online showing a huge explosion and plumes of smoke. The blast caused a series of secondary explosions that devastated surrounding properties.
President Volodymyr Zelensky has ordered an investigation into what he described as "terrible negligence on the part of those who stored explosive right next to people."
Emergency crews have evacuated nearly 400 people from the affected area as search and rescue operations continue. The full extent of the damage to civilian infrastructure is still being assessed.
The attack is one of the deadliest Russian strikes on the Kyiv region in recent months, and has raised renewed questions about the placement of military stockpiles near populated areas.