Science Corporation implants vision-restoring chip in first Stargardt disease patient

The PRIMA retinal implant, already available in Europe for age-related macular degeneration, is now being trialled for an inherited eye condition that affects central vision.

By LineZotpaper
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Science Corporation CEO Max Hodak announced at TechCrunch Disrupt that the company has implanted its PRIMA vision-restoring chip into a patient with Stargardt disease, an inherited eye disease that gradually destroys central vision. The procedure marks the first use of the implant for this condition, which is currently considered incurable.

Hodak, the former president and co-founder of Neuralink, explained that the company sees its work with PRIMA as part of a broader pursuit of brain-computer interfaces (BCIs). "The retina is part of the central nervous system," Hodak said. "We consider cochlear implants, retinal prostheses, motor prostheses, these are all different types of BCIs."

PRIMA is already commercially available in Europe for patients who have lost their sight to geographic atrophy, an advanced form of age-related macular degeneration. The company believes the same approach can be applied to multiple diseases, including Stargardt disease.

Stargardt disease affects the outer retina, causing the gradual death of the eye's light-sensing cells while potentially sparing the inner retina, which passes visual signals to the brain. It creates a central blind spot that enlarges over time. According to Hodak, approximately 150,000 people worldwide have lost vision due to the disease.

"One of the nice things about this device approach," Hodak said, "if you can get the optic nerve to signal the rest of the brain correctly, then you can provide vision to it." Hodak outlined a vision in which BCIs expand into a wide range of medical technology applications, beyond simply controlling computers.

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Analysis

Why This Matters

  • The first human implant for Stargardt disease offers a potential treatment pathway for a currently incurable condition that affects an estimated 150,000 people worldwide.
  • It represents an expansion of Science Corporation's PRIMA implant into a new indication, building on its existing European approval for geographic atrophy.
  • The work reinforces the broader trend of brain-computer interfaces moving beyond computer control into medical restoration of sensory function.

Background

Science Corporation is a neurotechnology company led by Max Hodak, who previously co-founded and served as president of Neuralink. The company's PRIMA implant is a subretinal photovoltaic chip designed to replace the function of degenerated photoreceptor cells. It was initially developed for age-related macular degeneration and received European regulatory approval for geographic atrophy. Stargardt disease is a genetic form of macular degeneration that typically begins in childhood or adolescence, causing progressive central vision loss.

Key Perspectives

[Science Corporation]: The company views the device as a versatile platform that can address multiple retinal diseases by electrically stimulating the inner retina, leveraging the fact that the optic nerve still functions. Hodak framed the approach as part of a broader BCI vision encompassing cochlear and motor prostheses. [Patients and clinicians]: For patients with Stargardt disease, who currently have no treatment options, a retinal implant that restores some vision would be transformative. However, clinical outcomes from the first implant will take time to evaluate. [Skeptics]: Retinal prostheses have historically faced challenges in providing meaningful visual acuity, and long-term safety and efficacy data for PRIMA in Stargardt disease are not yet available. The company will need to demonstrate consistent results across a larger patient population.

What to Watch

  • Clinical updates from the first Stargardt patient, including any reported restoration of light perception or pattern vision.
  • Expansion of the clinical trial to additional patients and sites.
  • Seeking of regulatory approval for Stargardt disease in Europe and potentially other regions.

Sources

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