During the visit, the royals will view an exhibition on the massive rescue effort and meet members of the Aberfan Wives support group for mothers who lost children. Prince William will later visit Ynysowen Community Primary School to unveil an Aberfan Memorial Tree.
The village's Ynysowen Male Voice Choir, formed in the aftermath of the disaster, is set to perform. Survivor Jeff Edwards, one of the last children pulled alive from the rubble, will be among those sharing personal reflections. He met Prime Minister Andy Burnham on Monday.
Mr Burnham called the 1966 tragedy 'one of the most horrifying tragedies this country has ever seen' and stressed the 'critical importance' of making remaining coal tips in Wales safe. He met survivors including Irene Hollett, a former Pantglas pupil. 'A lot of stuff comes back to you,' she said. 'You feel grateful that you are still around 60 years on, but then you miss your friends and family that we lost at the time. You can feel a bit of guilt that you are still here.'
The disaster struck on 21 October 1966 when a colliery spoil tip collapsed after heavy rain, burying Pantglas Junior School and surrounding houses. 116 children and 28 adults died.
Queen Elizabeth II's delayed response, arriving eight days after the tragedy, is a widely examined aspect of the disaster's history. Her former private secretary, Lord Charteris, said it was the biggest regret of her reign. The late Queen returned to Aberfan several times, and on the 50th anniversary King Charles, then Prince of Wales, read a personal message from her praising the community's 'remarkable fortitude, dignity and indomitable spirit'.